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49 CFR Part 382 reference
Last Updated: 09/24/2026

49 CFR Part 382, "Controlled Substances and Alcohol Use and Testing," applies to employers of drivers who need a commercial driver's license (CDL) and to the drivers themselves (49 CFR 382.103). It says who must be tested and when; the testing procedures themselves are in 49 CFR Part 40. The full current text is on eCFR.

What each subpart covers

SubpartCovers
A: GeneralApplicability, definitions (including "actual knowledge" and "safety-sensitive function"), and employer and driver responsibilities.
B: ProhibitionsAlcohol concentration of 0.04 or greater, on-duty and pre-duty alcohol use, controlled substance use, and refusals.
C: Tests requiredPre-employment, post-accident, random, reasonable suspicion, return-to-duty, and follow-up testing (382.301 to 382.311).
D: Handling of test results, records retention, and confidentialityRecordkeeping periods, the annual MIS summary, and previous employer checks.
E: Consequences for driversRemoval from safety-sensitive functions and referral to a SAP.
F: Education and trainingCompany policy, driver education, and supervisor training.
G: Drug and Alcohol ClearinghouseQueries, consent, reporting, registration, and corrections (382.701 to 382.727).

Clearinghouse sections (Subpart G)

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